The lab is supported by:

Canada Foundation for Innovation

Canadian Institutes of Health Research

Abstracts are available from PubMed. Full Text links work only if you have valid license from the publisher. If you don't have one and interested in the publication email me!

Published refereed papers

1, A.Sík, N.Tamamaki and T.F.Freund (1993) Complete axon arborization of single CA3 pyramidal cell in the hippocampus, with special reference to the distribution of postsynaptic parvalbumin-containing interneurons. E.J.Neurosci., 5(12):1719-1728 Abstract

2, A.I.Gulyas, R.Miles, A.Sík, K.Toth and T.F.Freund (1993) Hippocampal pyramidal neurons excite nonpyramidal cells via single release sites. Nature, 366(6456):683-687 Abstract

3, I.Nagy, A.Sík, E.Polgar, M.Petko and M.Antal (1994) Combination of cobalt labeling with immunocythochemical reactions for electron microscopy investigations on the frog spinal cord. Microscopy Research and Technique, 28(1):60-66 Abstract

4, M.G.Lee, J.J.Chrobak, A.Sík, R.G.Wiley and G.Buzsaki (1994) Hippocampal theta activity following selective lesion of the septal cholinergic system. Neurosci., 62(4):1033-1047 Abstract

5, A. Sik, A. Ylinen, M. Penttonen and G. Buzsaki (1994) Inhibitory CA1-CA3-hilar region feedback in the hippocampus. Science, 265(5179):1772-177 Abstract

6, A.Ylinen, A.Bragin, Z.Nadasdy, G.Jando, I.Szabo, A.Sík and G.Buzsaki (1995) Sharp wave-associated high frequency oscillation (200Hz) in the intact hippocampus: network and intracellular mechanism. J.Neurosci., 15(1 Pt 1):30-46 Abstract

7, A.Ylinen, I.Soltesz, A. Bragin, M. Penttonen, A.Sík and G. Buzsaki (1995) Intracellular correlates of hippocampal theta rhythm in identified pyramidal cells, granule cells, and basket cells. Hippocampus, 5(1):78-90 Abstract

8, A.Sík, M.Penttonen, A. Ylinen and G. Buzsaki (1995) Hippocampal CA1 interneurons: An in vivo intracellular labeling study. J.Neurosci., 15(10):6651-6665 Abstract

9, A.Sík, M.Penttonen and G. Buzsaki (1997) Interneurons in the dentate gyrus: An in vivo intracellular study. E.J.Neurosci., 9(3):573-588 Abstract

10, M.Penttonen, A.Kamondi, A.Sík, L.Acsady and G.Buzsaki (1997) Feed-forward and feed-back activation of the dentate gyrus in vivo during dentate EEG spikes and sharp wave bursts. Hippocampus, 7(4):437-450 Abstract

11, G.Pyapali, A.Sík, M.Penttonen, G.Buzsaki and D.Turner (1998) Dendritic properties of hippocampal CA1 pyramidal neurons in the rat: Intracellular staining in vivo and in vitro. J.Comp. Neurology, 391(3):335-52 Abstract Full Text

12, A.Sík, N.Hájos, A.Gulácsi, I.Mody and T.F.Freund (1998) The absence of a major Ca2+ signaling pathway in GABAergic neurons of the hippocampus. Proc.Natl.Acad.Sci. USA,95(6):3245-3250 Abstract Full Text

13, L.Acsady, A.Kamondi, A.Sík, T.F.Freund and G.Buzsaki (1998) GABAergic cells are the major postsynaptic targets of mossy fibers in the rat hippocampus. J.Neurosci., 18(9):3386-3403 Abtract Full Text

14, I.Katona, B.Sperlagh, A.Sík, A.Kofalvi, S.E.Vizi and T.F.Freund (1999) Presynaptically located CB1 cannabinoid receptors regulate GABA release from axon terminals of specific hippocampal interneurons. J.Neurosci., 19(11):4544-4558 Abstract Full Text

15, Z.Boldogkoi, F.Erdelyi, A.Sík, T.F.Freund and I.Fodor (1999) Construction of a recombinant herpesvirus expressing the jellyfish green fluorescent protein. Luminescence, 14(2):69-74 Abstract Full Text

16, A.Sík, A.Gulacsi, Y.Lai, W.K.Doyle, S.Pacia, I.Mody and T.F.Freund (2000) Localization of the A kinase anchoring protein AKAP79 in the human hippocampus. E.J.Neurosci., 12(4):1155-1164 Abstract Full Text

17, A.Sík, R. L.Smith, and T.F.Freund (2000) Distribution of chloride channel-2 immunoreactive neuronal and astrocytic processes in the hippocampus. Neurosci., 101(1): 51-65 Abstract Full Text

18, A.I. Gulyás, A.Sík, J.A.Payne, K.Kaila and T.F.Freund (2001) The K+/Cl- cotransporter (KCC2) is preferentially associated with sites of excitatory synaptic transmission in the developing and adult rat hippocampus. E.J.Neurosci., 13(12): 2205-2217 Abstract Full Text

19, V.Varga, A.Sík, T.F.Freund and B.Kocsis (2002) GABAB receptors in the median raphe nucleus: distribution and role in the serotonergic control of hippocampal activity. Neurosci., 109(1):112-132 Abstract Full Text

20, C.Varga, A.Sík, P.Lavallée and M.Deschênes (2002) Dendroarchitecture of relay cells in thalamic barreloids: a substrate for cross-whisker modulation. J.Neurosci., 22(14):6186-94. Abstract Full Text

21, Zs.Boldogköi, A.Reichart, I.Tóth, A.Sík, F.Erdélyi, I.Medveczky, C.Llorens-Cortes, M.Palkovits and Zs.Lenkei (2002) Construction ofrecombinant pseudorabies viruses optimized for labeling and neurochemical characterization of neural circuitry. Mol. Brain Res., 109(1-2) 103-116 Abstract

22, J.A.M.Coull, D.Boudreau, K.Bachand, S.A.Prescott, F.Nault, A.Sík, P.De Koninck and Y. De Koninck (2003) Transsynaptic shift in anionic gradient in spinal lamina I neurons as a novel mechanism of a painful periferial neuropathy. Nature 424(6951):938-42. Abstract

23, A.Gulácsi, C. R. Lee, A. Sík, T. Viitanen, K. Kaila, J. M. Tepper and T. F. Freund (2003) Cell type specific differences in the chloride regulatory mechanismsand GABAa receptor mediated inhibition in rat substantia nigra. J.Neuroscience 23(23):8237-46. Abstract Full text

24, A.Sík, BJ.Passer, EV.Koonin and L.Pellegrini (2004) Self-regulated cleavage of the mitochondrial intramembrane-cleaving protease PARL yields P-beta, a nuclear-targeted peptide. J.Biol.Chem.279(15):15323-9 Abstract Full text Evaluated in the Faculty of 1000

25, Zs.Boldogköi, A. Sík, Á.Dénes, A.Reichart, J.Toldi, I.Gerendai, K.Kovács and M.Palkovits (2004) Novel tracing paradigms – genetically engineered herpesviruses as tools for mapping functional circuits within the CNS: present status and future prospects. Progress in Neurobiology 72(6):417-45. Abstarct Full text

26, A.Hudmon, E.LeBel, H.Roy, A.Sík, H.Schulman, M.Waxham and P. De Koninck (2005) A Mechanism for CaMKII Clustering at Synaptic and Non-Synaptic Sites Based on Self-Association J.Neuroscience25(30)6971-83 Abstract Full text Evaluated in the Faculty of 1000

27, S.Li, V.Varga, A.Sík and B.Kocsis (2005) GABAergic control of the ascending serotonergic input to the limbic system J.Neurophysiol, 94:2561-2574 Abstract Full text

28, N.Kamasawa, A.Sík, M.Morita, T.Yasumura, K.G.V.Davidson, J.I.Nagy and J.E.Rash (2005) Ultrastructural demonstration of connexin-47 and connexin-32 in gap junctions on oligodendrocyte somata, myelin, Schmidt-Lanterman incisures and paranodal loops in rodent CNS Neuroscience, 2005;136(1):65-86. Abstract Full text

29, E.Timofeeva, C. Dufresne, A.Sík, Z.W. Zhang, and M. Deschênes (2005) Cholinergic modulation of vibrissal receptive fields in trigeminal nuclei J. Neuroscience, 25(40):9135-43. Abstract Full text

30, M.Urushitani, A.Sík,, T.Sakurai, N.Nukina, R.Takahashi and J.P.Julien (2006) Chromogranin-mediated secretion of ALS-linked superoxide dismutase mutants: a novel pathway to inflammation and motor neuron death Nature Neurosci., (1):108-18 Abstract Full text Evaluated in the Faculty of 1000

31, B.Kocsis, V.Varga, L.Dahan and A.Sík (2006) Serotonergic neuron diversity: identification of raphe neurons with discharges time-locked to the hippocampal theta rhythm Proc.Natl.Acad.Sci. USA, 103(4):1059-64 Abstract Full text

32, A.Sík, A.Coté and Zs. Boldogkői (2006) Selective spread of neurotropic herpes viruses in the rat hippocampus J. Comparative Neurology, 496(2):229-43 Abstract Full text

33, L.Davidovic, E.Bechara, M.Gravell, XH.Jaglin, S.Tremblay, A.Sík, B.Bardoni and EW. Khandjian (2006) The nuclear MicroSpherule Protein 58 is a novel RNA-binding protein that interacts with Fragile X Mental Retardation Protein in polyribosomal mRNPs from neurons Human Molecular Genetics, 15(9):1525-38 Abstract

34, J.Vinet and A.Sík (2006): Expression pattern of voltage-dependent calcium channel subunits in hippocampal inhibitory neurons in mice Neuroscience, 143(1):189-212  Abstract

35, M. Saint-Pierre, M.Tremblay, A.Sík and F. Cicchetti (2006): Temporal effects of paraquat/maneb on microglial activation and dopamine neuronal loss in older rats J. Neurochemistry, 98(3):760-772 Abstract

36, M.Levesque, MJ.Wallman, A.Sík* and A. Parent (2006): Neurokinin-1 and neurokinin-3 receptors in the primate substantia nigra, Neuroscience Research, 57(3):362-71, * co-corresponding author Abstract

37, M.Hajós, AA.Kelly, T.Sharp, G.Charette, A.Sík and B.Kocsis (2007): Stereotyped burst activity in a subset of neurochemically identified raphe 5-HT neurons in anaesthetized rats E.J. Neuroscience, 25(1):119-126 Abstract

38, M.Derchansky, S.S.Jahromi, M.Mamani,D.S. Shin, A.Sík and P.L.Carlen (2007): Transition to seizures in the isolated immature hippocampus: a switch from dominant phasic inhibition to dominant phasic excitation J.Physiology, 586(2):477-94 Abstract

39, K.Basu, C.Gravel, R.Tomioka, T.Kaneko, N.Tamamaki and A.Sík (2008): Novel strategy to selectively label excitatory and inhibitory neurons in the cerebral cortex of mice J. Neuroscience Methods, 170(2):212-9 Abstract

40, S. Tétrault, O. Chever, A.Sík * and F. Amzica (2008): Opening of the blood-brain barrier during isoflurane anesthesia Eur. J . Neuroscience, 28:1330-1341 * co-corresponding author

41, K. Kovács, A.Sík, C. Ricketts and I.Timofeev (2009) Subcellular distribution of low-voltage activated T-type Ca2+ channel subunits (Cav3.1 and Cav3.3) in reticular thalamic neurons of the cat J. Nerosci.Res. 88(2):448-460 Abstract

42, C. Capaday, C. Ethier, L. Brizzi L, A.Sík, C. van Vreeswijk, and D. Gingras (2009) On the Nature of the Intrinsic Connectivity of the Cat Motor Cortex: evidence for a recurrent neural network topology J. Neurophysiol. 102: 2131-2141 Abstract

43,  J.Vinet, P. Lemieux, A.Tamburri, P.Tiesinga, V.Gallo and A.Sík (2010): Different subclasses of oligodendrocytes populate mice adult hippocampus E. J. Neurosci.(31)425-38 Abstract

44, X. Li,  G.X. Ouyang, A.Usami, Y. Ikegaya and A.Sík (2010) Scale-free power-law distribution characterises functional neuronal assemblies of the hippocampal CA3  network Biophysical Journal 98(9)1733-41 Abstract

45, D.Kroeger, A.Tamburri, A., F.Amzica and A.Sík (2010) Activity dependent layer-specific changes in the extracellular chloride concentration and chloride driving force in the rat hippocampus in press J.Neurophysiology 103: 1905-1914 Abstract

46, B.Pary, A.Côté, V.Gallo, P.De Koninck and A.Sík: Functional coupling between astrocytes and oligodendrocytes via gap junctions in culture Neuroscience 167(4): 1032-1043 Abstract

47, J.Boucher , H.Kroger  and A.Sík (2010) Realistic modeling of receptor activation in hippocampal excitatory synapses: analysis of multivesicular release, release location, temperature and synaptic crosstalk  Brain structure and function 215(1):49-65 Abstract

48,Y.Shinohara, A.Hosoya, K.Yahagi, A.S.Ferecskó, K.Yaguchi, A.Sík, M.Itakura, M.Takahashi, and H. Hirase (2012) Hippocampal CA3 and CA2 have distinct bilateral innervation patterns to CA1 in rodents E.J.Neurosci. 35(5):702-10 Abstract

49,R.Blanch, Z.Ahmed, A.Sík, D.Snead, P.Good, M.Berry, R.Scott, and A.Logan (2012) Neuroretinal cell death in a murine model of closed globe injury; pathological and functional characterization Investigative Ophthalmology & Visual Science Abstract

50, K.Kovács, K.Basu, I.Rouiller, and A.Sík (2013): Regional differences in the expression of K+-Cl– 2 cotransporter in the developing rat neocortex, Brain structure and function Abstract

51, S.Gharanei, M.Zatyka, D.Astuti, J.Fenton, E.M Rabai, A.Sík, Z.Nagy and T.G.Barrett (2013) Vacuolar-type H+-ATPase V1A subunit is a molecular partner of Wolfram syndrome 1 (WFS1) protein, which regulates its stability and expression Human Molecular Genetics, 22(2):203-17 Abstract

52, S.S.Dhillon, E.Doro, I.Magyary, S.Eggington,  A.Sík* and F.Müller (2013) Optimisation of embryonic and larval ECG measurement in zebrafish for quantifying the effect of QT prolonging drugs Plos One,  * co-corresponding author Abstract

53, A.S. Ferecskó, P.Jiruska, L.Foss, A.D.Powell, W-C.Chang, A.Sík* and J.G.R.Jefferys (2013) Structural and functional substrates of tetanus toxin action in animal model of epilepsy Brain structure and function * co-corresponding author


Book Chapters

1, G.Buzsaki, A.Bragin, J.J.Chrobak, Z.Nadasdy, A.Sík, M.Hsu and A.Ylinen (1994) Oscillatory and intermittent synchrony in the hippocampus: relevance to memory trace formation. Temporal coding in the brain, Springer, 145-173

2, M.Hsu, A.Sík, F.Gallyas, Zs.Horvath and G.Buzsaki (1994) Short- term and long-term changes in the postischemic hippocampus. In: Hormonal Restructuring of the Adult Brain, The New York Acad. Sci., (743)121-140 Abstract

3, A.Sík (2006): Merging structure and function: Combination of in vivo extracellular and intracellular electrophysiological recordings with neuroanatomical techniques. In: Neuroanatomical tract-tracing 3: molecules-neurons-systems (Eds.: Z aborszky, Wouterlood, and Lanciego); Springer, New York, USA


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